PEG-MGF, or Pegylated Mechano Growth Factor, is a variant of Insulin-like Growth Factor-1 (IGF-1), known for its potential benefits in muscle and tissue repair. The peptide has been modified with polyethylene glycol (PEG), which enhances its stability and bioavailability in the body.
The primary mechanism of action of PEG-MGF involves the stimulation of myoblasts division and their subsequent differentiation into mature muscle fibers. Research suggests this process, known as myogenesis, contributes to muscle growth and repair. The peptide achieves this by binding to IGF-1 receptors on the surface of myoblasts, activating intracellular signaling pathways that promote cell proliferation and inhibit apoptosis.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2342624/
[2] https://pubmed.ncbi.nlm.nih.gov/9473336/
[3] https://pubmed.ncbi.nlm.nih.gov/16024511/
[4] https://pubmed.ncbi.nlm.nih.gov/12612647/
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