PTD-DBM, or Protein Transduction Domain – Dishevelled Binding Motif, is a synthetic peptide that holds promise in regenerative medicine and oncology. It modulates the Wnt/β-catenin pathway, affecting cell proliferation, differentiation, and survival. Research suggests by inhibiting Dvl-β-catenin interaction, PTD-DBM impedes the pathway, potentially slowing cancer growth or inducing cell death. Additionally, it influences stem cell differentiation, making it useful for tissue regeneration.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4493411/
[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC9831250/
[3] https://pubmed.ncbi.nlm.nih.gov/20641004/
[4] https://pubmed.ncbi.nlm.nih.gov/32050297/
[5] https://www.mdpi.com/2073-4409/12/4/555
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